Potassium Carbonate → 6-Methoxy-4-{2-[(2R)-oxiran-2-yl]ethyl}pyrido[2,3-b]pyrazin-3(4H)-one

HRID 1847072노트

반응식

HRID 1847072 반응식
CC1C=CC(S(O[CH2:12][C@H:13]([OH:29])[CH2:14][CH2:15][N:16]2[C:21](=[O:22])[CH:20]=[N:19][C:18]3[CH:23]=[CH:24][C:25]([O:27][CH3:28])=[N:26][C:17]2=3)(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:28][O:27][C:25]1[CH:24]=[CH:23][C:18]2[N:19]=[CH:20][C:21](=[O:22])[N:16]([CH2:15][CH2:14][C@@H:13]3[CH2:12][O:29]3)[C:17]=2[N:26]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 86724995(2R)-2-Hydroxy-4-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)butyl 4-methylbenzensulfonate

생성물 1

HCID 867249966-Methoxy-4-{2-[(2R)-oxiran-2-yl]ethyl}pyrido[2,3-b]pyrazin-3(4H)-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In methanol (250 ml) was dissolved (2R)-2-hydroxy-4-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)butyl 4-methylbenzensulfonate (4.30 g, 10.25 mmol), potassium carbonate (1.70 g, 12.30 mmol) was added thereto at room temperature and the mixture was stirred for 4 hours. The reaction solution was concentrated under reduced pressure and the residue was diluted with chloroform and washed with water. After drying the resultant over anhydrous sodium sulfate, the solvent was removed under reduced pressure and the obtained residue was purified by silica gel column chromatography (chloroform/methanol) to yield 2.62 g (quantitative) of the title compound in the form of a yellowish solid.

후처리

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. additionthe residue was diluted with chloroform
  4. washwashed with water
  5. dry with materialAfter drying the resultant over anhydrous sodium sulfate
  6. customthe solvent was removed under reduced pressure
  7. customthe obtained residue was purified by silica gel column chromatography (chloroform/methanol)

출처 및 근거

ORD 기록
ord-3332704ccac542afbf11c8b374062ae0
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952010B2

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