1-(3,3-Dimethoxypropyl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)one → 1-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one

HRID 1847082노트

반응식

HRID 1847082 반응식
[CH3:1][O:2][CH:3]([O:19][CH3:20])[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[NH:9][CH2:8][C:7]1=[O:18]>ClCCl.[O-2].[O-2].[Mn+4]>[CH3:20][O:19][CH:3]([O:2][CH3:1])[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[N:9]=[CH:8][C:7]1=[O:18]

참가 물질

4

반응물 1

HCID 867250051-(3,3-Dimethoxypropyl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)one

생성물 1

HCID 867249271-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one수율 72%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

In dichloromethane (10 ml) was dissolved 1-(3,3-dimethoxypropyl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)one (201 mg, 0.717 mmol) under a nitrogen gas atmosphere, manganese dioxide (733 mg, 7.17 mmol) was added thereto at room temperature and the mixture was stirred at the same temperature for 17 hours. The insoluble material was removed by filtration using celite, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane/ethyl acetate) to yield 143 mg (72%) of the title compound in the form of a yellowish solid.

후처리

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (n-hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-56529800bdd74b0d99adaf9d91dd2be2
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952010B2

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