Methanol → Methyl 3-fluoro-4-nitrobenzoate
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[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[CH3:14]O>>[CH3:14][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([F:1])[CH:3]=1참가 물질
3
실험 절차
A 1 L round bottom flask equipped with a stir bar and reflux condenser was charged 5H2SO4 (4 mL), methanol (400 mL) and 3-fluoro-4-nitrobenzoic acid (10 g). The reaction mixture was heated at reflux temperatures with vigorous stirring for 18 h. The methanol was removed and the crude residue was triturated with hexane and concentrated to give a colorless solid (9.79 g) that was used without further purification.
후처리
- customA 1 L round bottom flask equipped with a stir bar
- temperaturereflux condenser
- temperatureThe reaction mixture was heated
- temperatureat reflux temperatures
- customThe methanol was removed
- customthe crude residue was triturated with hexane
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-536115a2a5e24beb829c5c8865d8c9cb
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741355B2
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