Methanol → Methyl 3-fluoro-4-nitrobenzoate

HRID 18482

반응식

HRID 18482 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[CH3:14]O>>[CH3:14][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([F:1])[CH:3]=1

참가 물질

3

반응물 2

HCID 887MethanolHCID 2306533-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 592761Methyl 3-fluoro-4-nitrobenzoate

실험 절차

A 1 L round bottom flask equipped with a stir bar and reflux condenser was charged 5H2SO4 (4 mL), methanol (400 mL) and 3-fluoro-4-nitrobenzoic acid (10 g). The reaction mixture was heated at reflux temperatures with vigorous stirring for 18 h. The methanol was removed and the crude residue was triturated with hexane and concentrated to give a colorless solid (9.79 g) that was used without further purification.

후처리

  1. customA 1 L round bottom flask equipped with a stir bar
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux temperatures
  5. customThe methanol was removed
  6. customthe crude residue was triturated with hexane
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-536115a2a5e24beb829c5c8865d8c9cb
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741355B2

연결된 노트

불러오는 중…