5-Fluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile → (4,7-Difluoro-2-(methylthio)benzo[d]thiazol-6-yl)methanamine

반응식

[F:1][C:2]1[C:7]2[N:8]=[C:9]([S:11][CH3:12])[S:10][C:6]=2[C:5]([F:13])=[C:4]([C:14]#[N:15])[CH:3]=1.FC1C(C#N)=CC2SC(SC)=NC=2C=1>>[F:1][C:2]1[C:7]2[N:8]=[C:9]([S:11][CH3:12])[S:10][C:6]=2[C:5]([F:13])=[C:4]([CH2:14][NH2:15])[CH:3]=1

참가 물질

반응물 2

HCID 866811685-Fluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile

HCID 866811724,7-Difluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile

생성물 1

HCID 86681175(4,7-Difluoro-2-(methylthio)benzo[d]thiazol-6-yl)methanamine

실험 절차

(4,7-Difluoro-2-(methylthio)benzo[d]thiazol-6-yl)methanamine was synthesized as a clear oil (646 mg, 64%) using a procedure analogous to that described in Step 3 of Example 154, substituting 4,7-difluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile from the previous step for 5-fluoro-2-(methylthio)benzo[d]thiazole-6-carbonitrile used in Example 154. LCMS (ESI) m/z 247 (M+H)+.

출처 및 근거

ORD 기록: ord-49b402b7a0034b97a2561bee2e960344
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08952058B2

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