Morpholine → 4-(Morpholin-4-yl)pyridin-2-amine
반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>CC(N(C)C)=O>[O:12]1[CH2:13][CH2:14][N:9]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=2)[CH2:10][CH2:11]1참가 물질
4
반응 조건
- 온도
- 200 °C
실험 절차
A mixture of 4-chloropyridin-2-amine (400 mg, 3.1 mmol) and morpholine (2 mL) in 2 mL of DMA was heated at 200° C. for 5 min in a microwave reactor. LCMS analysis indicated completion of the reaction. The mixture was partitioned between EtOAc and brine, and the organic layer was dried over Na2SO4 and concentrated under reduced pressure to give crude 4-morpholinopyridin-2-amine as a yellow solid (350 mg). LCMS (ESI) m/z 180 (M+H)+.
후처리
- customcompletion of the reaction
- customThe mixture was partitioned between EtOAc and brine
- dry with materialthe organic layer was dried over Na2SO4
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-9daf0ffe0a204f6c8230df2a2f509553
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08952058B2
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