Bromine → HCID 178508959, 화합물

HRID 1848361노트

반응식

HRID 1848361 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[N:3]=1.[Br:9]Br>C(O)(=O)C>[NH2:1][C:2]1[N:3]=[C:4]([OH:8])[CH:5]=[CH:6][C:7]=1[Br:9]

참가 물질

4

반응물 2

HCID 24408BromineHCID 1785076342-Amino-6-hydroxypyridine

생성물 1

HCID 178508959HCID 178508959, 화합물수율 68.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Under an argon atmosphere 2-amino-6-hydroxy-pyridine (19.6 g, 178 mmol) was suspended in acetic acid (100%, 390 mL). Br2 (9.2 mL, 178 mmol) was added at 20° C. over 5 min. The green suspension was stirred at RT for 20 min. The mixture was poured onto H2O (400 mL) and filtered. The filtrate was mixed with brine (200 mL) and extracted with EtOAc (10×400 mL). The combined organic phases were dried (Na2SO4), filtered and concentrated to afford 6-Amino-5-bromo-pyridin-2-ol as a yellow solid (23 g).

후처리

  1. additionThe mixture was poured onto H2O (400 mL)
  2. filtrationfiltered
  3. additionThe filtrate was mixed with brine (200 mL)
  4. extractionextracted with EtOAc (10×400 mL)
  5. dry with materialThe combined organic phases were dried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-67d97185f367497a8a7718dd8ad8a328
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952162B2

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