3-Borono-4-chlorobenzoic acid → 4-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acid
반응식
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([Cl:13])=[C:8](B(O)O)[CH:9]=1)([OH:3])=[O:2].Br[C:15]1[C:20]([C:21]#[N:22])=[CH:19][C:18]([C:23]([F:26])([F:25])[F:24])=[N:17][CH:16]=1>>[Cl:13][C:7]1[C:8]([C:15]2[CH:16]=[N:17][C:18]([C:23]([F:25])([F:26])[F:24])=[CH:19][C:20]=2[C:21]#[N:22])=[CH:9][C:4]([C:1]([OH:3])=[O:2])=[CH:5][CH:6]=1참가 물질
3
실험 절차
Similarly, 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acid was prepared according to the above procedure from 5-carboxy-2-chloro-phenylboronic acid and 5-bromo-2-trifluoromethyl-isonicotinonitrile 1-1.
출처 및 근거
- ORD 기록
- ord-87e7f4062b764a1893a159aab41d6a8e
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08952161B2
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