3-Hydroxybenzaldehyde → 3-(Dimethylaminomethyl)phenol

HRID 1848806

반응식

HRID 1848806 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][NH:11][CH3:12].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].CO>C1COCC1.C(Cl)Cl>[CH3:10][N:11]([CH2:5][C:4]1[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=1)[CH3:12]

참가 물질

7

반응물 4

HCID 1013-HydroxybenzaldehydeHCID 674DimethylamineHCID 887MethanolHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 328963-(Dimethylaminomethyl)phenol

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

3-Hydroxybenzaldehyde (1.0 g), 2M dimethylamine in THF (5 mL), and sodium triacetoxyborohydride (2 g) in CH2Cl2 (10 mL) were stirred for 24 hours. The mixture was treated with methanol and chromatographed on silica gel with 2-25% ethyl acetate/hexanes.

후처리

  1. customchromatographed on silica gel with 2-25% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-df5af0ca9d194e2f9c958e27b101116e
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952157B2

연결된 노트

불러오는 중…