Thionyl Chloride → 5-Chloromethyl-2-(4-chlorophenyl)thiazole
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH2:13]O)=[CH:11][N:12]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:13][C:10]1[S:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[N:12][CH:11]=1참가 물질
4
실험 절차
To a suspension of [2-(4-chlorophenyl)thiazol-5-yl]methanol (3.24 g, 14.3 mmol) in dichloromethane (40 ml) is added dropwise the thionyl chloride (1.3 ml, 18 mmol) at room temperature under nitrogen. The reaction mixture is stirred at room temperature for 4 hours. Silica gel is added to the crude reaction mixture, the solvent is evaporated under reduced pressure and the residue is purified by flash chromatography on silica gel to give 5-chloromethyl-2-(4-chlorophenyl)thiazole (3.24 g)
후처리
- additionSilica gel is added to the crude
- customreaction mixture
- customthe solvent is evaporated under reduced pressure
- customthe residue is purified by flash chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-0b240d2eaf9645ea991853f99463f79f
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08956999B2
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