3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)- → 5-Chloro-6-(2,2,2-trifluoroethoxy)nicotinaldehyde
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:14][OH:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11]>CCOC(C)=O.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:7]([O:8][CH2:9][C:10]([F:12])([F:13])[F:11])=[N:6][CH:5]=[C:4]([CH:3]=1)[CH:14]=[O:15]참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
To a solution of (5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanol (4.00 g, 16.56 mmol) in EtOAc (15 mL) was added manganese(IV) oxide (16.93 g, 166 mmol). The reaction was heated with microwave at 120° C. for 30 minutes. The mixture was then filtered through a pad of celite, and rinsed with EtOAc. The filtrated was concentrated to give crude product (3.38 g).
후처리
- filtrationThe mixture was then filtered through a pad of celite
- washrinsed with EtOAc
- concentrationThe filtrated was concentrated
출처 및 근거
- ORD 기록
- ord-10f7756815304a0794c2880cc5f266e1
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957068B2
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