7-(2,4-Dimethoxy-benzyl)-2-oxa-7-aza-spiro[3.5]nonane → 2-Oxa-7-azaspiro[3.5]nonane
반응식
COC1C=C(OC)C=CC=1C[N:6]1[CH2:14][CH2:13][C:9]2([CH2:12][O:11][CH2:10]2)[CH2:8][CH2:7]1>CO.[OH-].[OH-].[Pd+2]>[CH2:10]1[C:9]2([CH2:13][CH2:14][NH:6][CH2:7][CH2:8]2)[CH2:12][O:11]1참가 물질
4
실험 절차
To a solution of 7-(2,4-Dimethoxy-benzyl)-2-oxa-7-aza-spiro[3.5]nonane (125) (300 mg, 1.1 mmol) in MeOH (10 mL) was added Pd(OH)2 (300 mg). The reaction solution was stirred at RT overnight under H2 atmosphere. LCMS showed that most of the staring material was consumed. The mixture was filtered and concentrated to give the product (126) (112 mg, 0.88 mmol, yield: 80%). ESI-MS (M+1): 128 calc. for C7H13NO 127.
후처리
- customwas consumed
- filtrationThe mixture was filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-605acc0ffe414be1973040b23ca43039
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957073B2
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