Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-2-chlorotoluene → 1-(3-Chloro-4-methylphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-2-chlorotoluene | HCID 2735554 | — |
| 반응물 | HCID 66759981 | HCID 66759981 | — |
| 생성물 | 1-(3-Chloro-4-methylphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 59485015 | 58% |
반응 단계
By using 1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine hydrochloric acid salt (311 mg, 1.00 mmol) synthesized in Reference example 147 and 4-bromo-2-chloro-1-methylbenzene (308 mg, 1.50 mmol), the reaction was carried out in the same manner as Example 23 to obtain the title compound 213 mg (yield 58%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08957069B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-c5a563e6f3904bdea15fdd2f3b1293e8 |
| 출처 메모 | uspto-grants-2015_02 |