1-(2,4-Dimethoxyphenyl)piperazine → 1-(2,4-Dimethoxyphenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
반응식
Br[C:2]1[C:3]([CH3:14])=[C:4]([CH3:13])[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]=1[CH3:12].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[N:25]1[CH2:26][CH2:27][N:28]([C:2]2[C:3]([CH3:14])=[C:4]([CH3:13])[C:5]3[O:9][CH:8]([CH3:10])[CH2:7][C:6]=3[C:11]=2[CH3:12])[CH2:29][CH2:30]1참가 물질
3
실험 절차
By using 5-bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran (480 mg, 1.88 mmol) synthesized in Reference example 53 and 1-(2,4-dimethoxyphenyl)piperazine (627 mg, 2.82 mmol), the reaction was carried out in the same manner as Example 1 to obtain the title compound 400 mg (yield 54%).
출처 및 근거
- ORD 기록
- ord-75a7112ca4884855a805adb14baa3f98
- 출처 데이터셋
- uspto-grants-2015_02