1-(p-Chlorophenyl)cyclobutanecarboxylic acid → N-[2-(3-Bromo-4-methoxyphenyl)ethyl]-1-(4-chlorophenyl)cyclobutanecarboxamide

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([OH:14])=O)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Br:15][C:16]1[CH:17]=[C:18]([CH2:24][CH2:25][NH2:26])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>>[Br:15][C:16]1[CH:17]=[C:18]([CH2:24][CH2:25][NH:26][C:12]([C:8]2([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[CH2:9][CH2:10][CH2:11]2)=[O:14])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

참가 물질

반응물 2

HCID 6027611-(p-Chlorophenyl)cyclobutanecarboxylic acid

HCID 27355812-(3-Bromo-4-methoxyphenyl)ethan-1-amine

생성물 1

HCID 66869425N-[2-(3-Bromo-4-methoxyphenyl)ethyl]-1-(4-chlorophenyl)cyclobutanecarboxamide

실험 절차

Prepared from 1-(4-chlorophenyl)cyclobutanecarboxylic acid and 2-(3-bromo-4-methoxyphenyl)ethanamine following the procedure described in example 85, step 1.

출처 및 근거

ORD 기록: ord-2ec90c8e63404e7094eab1ecaae5c992
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08957089B2

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