Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Bromoacetyl bromide | HCID 61147 | — |
| 반응물 | 2-Amino-5-chloropyridine | HCID 66174 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide | HCID 3421110 | — |
반응 단계
To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741341B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-31ec5a5ff49240e090abf794e19ea941 |
| 출처 메모 | uspto-grants-2010_06 |