2-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt → HCID 178505975, 화합물

HRID 1851256노트

반응식

HRID 1851256 반응식
[F:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1.Cl.[NH:26]1[CH2:29][CH:28]([C:30]2[NH:34][N:33]=[C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[N:31]=2)[CH2:27]1>>[F:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH2:15][N:26]4[CH2:27][CH:28]([C:30]5[N:31]=[C:32]([C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=6)[NH:33][N:34]=5)[CH2:29]4)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1

참가 물질

3

반응물 2

HCID 687522832-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride saltHCID 866306594-(3-Fluoro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

생성물 1

HCID 178505975HCID 178505975, 화합물수율 57.6%

실험 절차

This compound was prepared in analogy by reacting 90 mg (0.28 mmol) 4-(3-fluoro-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzaldehyde with 93 mg (0.34 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt according to the procedure in example 1. After four and a half hours the reaction mixture was worked up and purified in the usual way as described in example 1. 81 mg of the desired product were obtained.

후처리

  1. customThis compound was prepared in analogy
  2. waitAfter four and a half hours the reaction mixture was worked up
  3. custompurified in the usual way

출처 및 근거

ORD 기록
ord-4b171b676b314596840d16651b3db474
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957064B2

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