Triethylamine → HCID 178424645, 화합물
반응식
[NH:1]1[CH2:4][CH:3]([C:5]2[NH:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=3)[N:6]=2)[CH2:2]1.C([N:19]([CH2:22]C)[CH2:20][CH3:21])C.C1([C:27]2[CH:34]=[C:33]([C:35]3[C:40]([C:41]4[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=4)=[CH:39][N:38]4[N:48]=CN=C4[N:36]=3)[CH:32]=[CH:31][C:28]=2[CH:29]=O)CC1.[BH-](OC(C)=O)(OC(C)=O)O[C:53]([CH3:55])=O.[Na+]>CN1C(=O)CCC1.C(O)(=O)C>[CH:21]1([C:20]2[N:19]=[C:22]3[N:36]=[C:35]([C:33]4[CH:34]=[CH:27][C:28]([CH2:29][N:1]5[CH2:4][CH:3]([C:5]6[N:6]=[C:7]([C:10]7[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=7)[NH:8][N:9]=6)[CH2:2]5)=[CH:31][CH:32]=4)[C:40]([C:41]4[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=4)=[CH:39][N:38]3[N:48]=2)[CH2:55][CH2:53]1참가 물질
7
반응물 4
생성물 1
시약·촉매·용매 2
실험 절차
164.5 mg 2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridine×2HCl (60% pure) are dissolved in 4.2 mL NMP. After addition of 0.16 mL triethylamine the reaction mixture is stirred for one hour. 350 mg 2-cyclopropyl-4-[6-(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]-benzaldehyde (50% pure) and 0.05 mL acetic acid are added. The reaction mixture is stirred overnight at room temperature. 113.8 mg (0.54 mmol) NaBH(OAc)3, are added in portions and the reaction mixture is stirred at room temperature for 18 hours. After the usual work-up and chromatography 167 mg (58.3%) of the desired product are obtained.
후처리
- stirringThe reaction mixture is stirred overnight at room temperature
- stirringthe reaction mixture is stirred at room temperature for 18 hours
출처 및 근거
- ORD 기록
- ord-f65bfb8561a444c698cfed32a32afd99
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957064B2
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