Lawesson's reagent → 7-nitro-1H-indole-2-carbothioamide
반응식
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13]([NH2:15])=O)=[CH:9]2)([O-:3])=[O:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:25])=CC=1>O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13](=[S:25])[NH2:15])=[CH:9]2)([O-:3])=[O:2]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of 7-nitro-1H-indole-2-carboxamide (2.50 g), Lawesson's reagent (5.42 g) and tetrahydrofuran (50 mL) was stirred at 50° C. overnight. The reaction mixture was concentrated, and the resulting crystals were filtrated, washed with toluene, and dried to give the title compound (2.08 g, yield 77%) as yellow crystals. melting point>237° C. (decomposition).
후처리
- concentrationThe reaction mixture was concentrated
- filtrationthe resulting crystals were filtrated
- washwashed with toluene
- customdried
출처 및 근거
- ORD 기록
- ord-5e685f5067724c0088bef8be3ea2ff52
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957070B2
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