Ethanol → HCID 11978594, 화합물

HRID 1851427노트

반응식

HRID 1851427 반응식
[C:1]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH:12][S:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:15])=[O:14])#[N:2].N[CH2:22][CH2:23][SH:24].C(O)C>O>[S:24]1[CH2:23][CH2:22][N:2]=[C:1]1[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH:12][S:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:14])=[O:15]

참가 물질

5

반응물 3

HCID 702EthanolHCID 6058CysteamineHCID 57901755HCID 57901755, 화합물

생성물 1

HCID 11978594HCID 11978594, 화합물수율 29.4%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of N-(2-cyano-1H-indol-7-yl)thiophene-2-sulfonamide (0.54 g), 2-aminoethanethiol (0.14 g) and ethanol (20 mL) was stirred at 60° C. overnight. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried. The obtained crystals were subjected to silica gel column chromatography, and eluted with ethyl acetate. The eluate was treated with activated carbon and concentrated to give the title compound (0.19 g, yield 29%) as colorless crystals. The crystals were recrystallized from ethyl acetate-hexane. melting point 189-190° C.

후처리

  1. filtrationthe obtained crystals were filtrated
  2. washwashed with water
  3. customdried
  4. washeluted with ethyl acetate
  5. additionThe eluate was treated with activated carbon
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2b76a62c22b84eea8cf4a66740f73062
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957070B2

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