Ethanol → HCID 136060800, 화합물

HRID 1851517노트

반응식

HRID 1851517 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19](=[S:21])[NH2:20])=[CH:15]2)(=[O:8])=[O:7].Br[CH2:23][C:24](=O)[C:25]([O:27][CH2:28][CH3:29])=[O:26].C(O)C.CN(C)C(=O)C>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]1[S:21][CH:23]=[C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=1)=[CH:15]2)(=[O:7])=[O:8]

참가 물질

6

반응물 4

HCID 702EthanolHCID 31374DimethylacetamideHCID 66144Ethyl bromopyruvateHCID 57901763HCID 57901763, 화합물

생성물 1

HCID 136060800HCID 136060800, 화합물수율 36.3%

시약·촉매·용매 1

HCID 962Water용매

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온도
80 °C

실험 절차

A mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide (0.30 g), ethyl bromopyruvate (0.21 g), ethanol (2 mL) and N,N-dimethylacetamide (2 mL) was stirred at 80° C. for 4 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried. The obtained crystals were recrystallized from ethyl acetate to give the title compound (0.14 g, yield 36%) as pale-yellow crystals. melting point 240-241° C.

후처리

  1. filtrationthe obtained crystals were filtrated
  2. washwashed with water
  3. customdried
  4. customThe obtained crystals were recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-d5675cef08c6442fa90391e097f69713
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957070B2

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