m-Chloroperbenzoic acid → Isoquinoline, 4-cyclopropyl-, 2-oxide
반응식
[CH:1]1([C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]=[N:6][CH:5]=2)[CH2:3][CH2:2]1.C1C=C(Cl)C=C(C(OO)=[O:22])C=1>C(Cl)Cl>[CH:1]1([C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]=[N+:6]([O-:22])[CH:5]=2)[CH2:3][CH2:2]1참가 물질
4
실험 절차
To a solution of 4-cyclopropylisoquinoline (0.4 g, 2.364 mmol) in DCM (10 ml) was added m-CPBA (1.224 g, 7.09 mmol) at room temperature. The reaction mass was stirred at the same temperature for 18 h. The reaction mass was diluted with DCM and washed with water and aqueous sodium bicarbonate solution. The combined organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get desired compound (0.35 g, 80%) as solid. The crude compound was taken further without purification.
후처리
- washwashed with water and aqueous sodium bicarbonate solution
- dry with materialThe combined organic layer was dried over anhydrous Na2SO4
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-d49eff751acf483f92974daf031eb141
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957203B2
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