Dimethylamine → HCID 70978361, 화합물

HRID 1852271노트

반응식

Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5](=[O:14])[NH:4][CH:3]=1.[CH3:15][NH:16][CH3:17]>>[CH3:15][N:16]([CH3:17])[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5](=[O:14])[NH:4][CH:3]=1

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 579564624-Bromo-6-methoxyisoquinolin-1(2H)-one

생성물 1

HCID 70978361HCID 70978361, 화합물수율 116.2%

실험 절차

A solution of 4-bromo-6-methoxyisoquinolin-1(2H)-one (1 g, 3.94 mmol) in dimethylamine (5 ml, 39.5 mmol) was heated to 105° C. for 48 h. After cooling, the reaction mixture was concentrated under reduced pressure to get 4-(Dimethylamino)-6-methoxyisoquinolin-1(2H)-one (0.8 g, 4.58 mmol, 85% yield). MS: MS m/z 219.20 (M++1).

후처리

temperatureAfter cooling
concentrationthe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-644c4ba85e754b3b8f64bad0b14b3bde
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08957203B2

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