4-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene → 2-[2-(2-Aminophenoxy)ethoxy]-4-methylaniline

HRID 1852366노트

반응식

HRID 1852366 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[C:4]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-])=O)[CH:3]=1>[Pd].O1CCOCC1>[NH2:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH2:13][CH2:12][O:11][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=1[NH2:8]

참가 물질

4

반응물 1

HCID 27630554-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene

생성물 1

HCID 136852532-[2-(2-Aminophenoxy)ethoxy]-4-methylaniline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 312751,4-Dioxane용매

실험 절차

100 g 4-methyl-1-nitro-2-(2-(2-nitro-phenoxy)-ethoxy)-benzene and 10 g palladium on charcoal were suspended in 3.5 l dioxane and hydrogenated at room temperature under a hydrogen pressure of 5.5 bar. After flashing three times with nitrogen the catalyst was filtered off under a nitrogen atmosphere and the remaining solution was evaporated and the product was dried under vacuum. Yield: 80 g.

후처리

  1. filtrationwas filtered off under a nitrogen atmosphere
  2. customthe remaining solution was evaporated
  3. customthe product was dried under vacuum

출처 및 근거

ORD 기록
ord-8649fc206d834f878209c93193575a1d
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962338B2

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