Nitrogen → 6-Oxospiro[2.5]octane-5-carbonitrile

HRID 1852473노트

반응식

HRID 1852473 반응식
[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:7][CH2:6]2)[CH:4]=[C:3]1[C:10]#[N:11].N#N>CO.[Pd]>[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:6][CH2:7]2)[CH2:4][CH:3]1[C:10]#[N:11]

참가 물질

5

반응물 2

HCID 947NitrogenHCID 867310096-Oxospiro[2.5]oct-4-ene-5-carbonitrile

생성물 1

HCID 867310106-Oxospiro[2.5]octane-5-carbonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

6-Oxospiro[2.5]oct-4-ene-5-carbonitrile (0.16 g, 1.1 mmol) was dissolved in MeOH (11 mL) and combined with 10% palladium on activated carbon (0.12 g, 0.11 mmol). The resulting mixture was subjected to alternating vacuum and H2 gas (4×). The mixture was then stirred under an atmosphere of H2 (50 psi) for 16 hours. The mixture was then subjected to alternating vacuum and N2 gas (4×). The mixture was filtered through celite and rinsed with MeOH. The filtrate was concentrated in vacuo to afford the title compound. The material was used without further purification.

후처리

  1. filtrationThe mixture was filtered through celite
  2. washrinsed with MeOH
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-0c79da19d7264276beaac0fcf37660f1
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962608B2

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