Lithium borohydride → 6-Hydroxyspiro[2.5]octane-5-carbonitrile

HRID 1852474노트

반응식

HRID 1852474 반응식
[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:7][CH2:6]2)[CH2:4][CH:3]1[C:10]#[N:11].[BH4-].[Li+]>C1COCC1.O>[OH:1][CH:2]1[CH2:9][CH2:8][C:5]2([CH2:6][CH2:7]2)[CH2:4][CH:3]1[C:10]#[N:11]

참가 물질

5

반응물 2

HCID 4148881Lithium borohydrideHCID 867310106-Oxospiro[2.5]octane-5-carbonitrile

생성물 1

HCID 867310116-Hydroxyspiro[2.5]octane-5-carbonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 6-oxospiro[2.5]octane-5-carbonitrile (130 mg, 0.87 mmol) in THF (4.3 mL) was stirred at ambient temperature and lithium borohydride (76 mg, 3.5 mmol) was added. The resulting mixture was stirred at ambient temperature for 16 hours. The mixture was diluted with water and extracted with EtOAc (2×). The combined organic extracts were washed with water, brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford the title compound. The material was used without further purification.

후처리

  1. extractionextracted with EtOAc (2×)
  2. washThe combined organic extracts were washed with water, brine
  3. dry with materialdried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-713ed157942f44dbadb358a83569b8a8
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962608B2

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