Methanol → HCID 59625678, 화합물

HRID 1852569

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HRID 1852569 반응식
C([N:14]1[CH2:17][CH:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])[CH2:20][CH2:19]2)[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.ClC(OC(Cl)C)=O.CO.CCOCC>C(Cl)Cl>[NH:14]1[CH2:15][CH:16]([N:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:29])[C:25]([F:26])([F:27])[F:28])[CH2:22][CH2:23]2)[CH2:17]1

참가 물질

6

반응물 4

HCID 887MethanolHCID 3283Diethyl EtherHCID 5213051-Chloroethyl chloroformateHCID 596259751-[4-(1-Benzhydryl-azetidin-3-yl)-piperazin-1-yl]-2,2,2-trifluoro-ethanone

생성물 1

HCID 59625678HCID 59625678, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

To a solution of compound 1f (2.11 g, 5.23 mmol) in CH2Cl2 (60 mL) was added 1-chloroethyl chloroformate (2.0 mL, 18.35 mmol) at 0° C. under N2. The mixture was stirred at 0° C. for 90 min and then MeOH (4 mL) was added. The mixture was refluxed for 1 h. Upon cooling, Et2O (50 mL) was added to the mixture. The resulting solid was collected by filtration and dried. The crude compound 1g was used in the next reaction without further purification. MS m/z (M+H+) 238.1.

후처리

  1. temperatureThe mixture was refluxed for 1 h
  2. temperatureUpon cooling
  3. filtrationThe resulting solid was collected by filtration
  4. customdried
  5. customThe crude compound 1g was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-175b4ed940a0420d8b31bfa79c6c33b1
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962607B2

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