Sodium Bicarbonate → HCID 178497569, 화합물

HRID 1852590노트

반응식

HRID 1852590 반응식
[NH2:1][C:2]1[C:3]([NH:12][C:13](=O)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].C([O-])(O)=O.[Na+]>C(O)(=O)C>[C:14]1([C:13]2[NH:12][C:3]3[C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:9][CH:10]=[CH:11][C:2]=3[N:1]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 59625820HCID 59625820, 화합물

생성물 1

HCID 178497569HCID 178497569, 화합물수율 71.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 810 mg (3.0 mmol) of methyl 3-amino-2-benzoylamino-benzoate 9y in 15 ml acetic acid was heated to 125° C. for 1.5 h. The reaction was cooled and poured into ice/water. The aqueous layer was made basic with NaHCO3 and extracted with CH2Cl2. The organic solution was dried over Na2SO4 and evaporated to give 540 mg (71%) of methyl 2-phenyl-1H-benzo[d]imidazole-7-carboxylate, 9z. MS m/z (M+H+) 253.2

후처리

  1. temperatureThe reaction was cooled
  2. extractionextracted with CH2Cl2
  3. dry with materialThe organic solution was dried over Na2SO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-04d19b586e83432eb16c72fee16dbbb9
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962607B2

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