4-(4-Nitrophenyl)-morpholin-3-ON → 4-(4-Aminophenyl)morpholin-3-one

HRID 18526

반응식

HRID 18526 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][C:11]2=[O:16])=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C.C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][C:11]2=[O:16])=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 114473754-(4-Nitrophenyl)-morpholin-3-ON

생성물 1

HCID 111948544-(4-Aminophenyl)morpholin-3-one

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2.6 g 4-(4-Nitro-phenyl)-morpholin-3-one in 350 mL ethyl acetate and 17 mL ethanol, 13.2 g SnCl2 dihydrate were added and the reaction mixture was heated to reflux for 2 h. Then, after cooling to RT the mixture was stirred for 16 h. The precipitated product was collected by filtration and was pure enough for the next reaction step. Yield: 2.07 g.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 2 h
  3. filtrationThe precipitated product was collected by filtration
  4. customwas pure enough for the next reaction step

출처 및 근거

ORD 기록
ord-2658f6e73fb0463f89f23ccdd224c989
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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