HCID 178452762, 화합물 → HCID 178461256, 화합물

HRID 1852702노트

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HRID 1852702 반응식
[Cl:1][C:2]1[C:7]([NH:8][CH2:9][C@H:10]2[CH2:15][CH2:14][C@H:13]([CH3:16])[CH2:12][CH2:11]2)=[C:6]([NH:17]C(=O)OC(C)(C)C)[CH:5]=[C:4]([Cl:25])[N:3]=1>Cl.O1CCOCC1>[Cl:1][C:2]1[C:7]([NH:8][CH2:9][C@H:10]2[CH2:11][CH2:12][C@H:13]([CH3:16])[CH2:14][CH2:15]2)=[C:6]([NH2:17])[CH:5]=[C:4]([Cl:25])[N:3]=1

참가 물질

3

반응물 1

HCID 178452762HCID 178452762, 화합물

생성물 1

HCID 178461256HCID 178461256, 화합물

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

A solution of tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate (150 g, 0.386 mol) in HCl/1,4-dioxane (4 M, 3.0 L) was stirred at 45° C. for 15 h. The mixture was concentrated under reduced pressure to give crude 2,6-dichloro-N3-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0b33c32f523d4018b35b14d010600496
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962611B2

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