HCID 178525710, 화합물 → HCID 178520945, 화합물
반응식
[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1>C1COCC1>[F:1][C:2]([F:12])([F:13])[C@H:3]1[CH2:4][CH2:5][C@H:6]([CH2:9][OH:10])[CH2:7][CH2:8]1참가 물질
3
실험 절차
BH3 (100 mL, 0.1 mol, 1.0 M solution in THF) was added dropwise to 0° C. solution of trans-4-(trifluoromethyl)cyclohexanecarboxylic acid (19.6 g, 0.1 mol) in dry THF (100 mL). The reaction was stirred at room temperature for 5 h, quenched with water, extracted with EtOAc, washed with brine, dried over Na2SO4, filtered, and concentrated to give [trans-4-(trifluoromethyl)cyclohexyl]methanol. 1H NMR (300 MHz, CDCl3): δ 3.48-3.47 (d, 2H), 2.00-1.89 (m, 5H), 1.51-1.43 (m, 1H), 1.35-1.26 (m, 2H), 1.05-0.96 (m, 2H).
후처리
- customquenched with water
- extractionextracted with EtOAc
- washwashed with brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-2408c22f990c4291aea1e83b1ea0d6c9
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08962611B2
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