Methyl 2-acetamidoacrylate → Methyl 7-chloroisoquinoline-3-carboxylate

반응식

Br[C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=O.C([NH:14][C:15](=[CH2:20])[C:16]([O:18][CH3:19])=[O:17])(=O)C>>[Cl:10][C:7]1[CH:6]=[C:3]2[C:2]([CH:20]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[N:14]=[CH:4]2)=[CH:9][CH:8]=1

참가 물질

반응물 2

HCID 98644Methyl 2-acetamidoacrylate

HCID 153912792-Bromo-5-chlorobenzaldehyde

생성물 1

HCID 17842489Methyl 7-chloroisoquinoline-3-carboxylate수율 25%

실험 절차

methyl 7-chloro-isoquinoline-3-carboxylate was prepared using the procedure described in example 12A: 2-bromo-5-chlorobenzaldehyde was reacted with methyl 2-acetamidoacrylate at 110° C. for 24 hours to yield methyl 7-chloro-isoquinoline-3-carboxylate (25%) as brown solid.

후처리

custommethyl 7-chloro-isoquinoline-3-carboxylate was prepared

출처 및 근거

ORD 기록: ord-ffda6479c38f4da3a4e42b85c693c17d
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08962627B2

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