4-(2-Chloro-ethyl)-2,6-dimethyl-morpholine hydrochloride → 6-[2-(2,6-Dimethyl-morpholin-4-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride

HRID 1853346노트

반응식

HRID 1853346 반응식
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]=2)=[CH:8]1)(C)(C)C.Cl.[Cl:28][CH2:29][CH2:30][N:31]1[CH2:36][CH:35]([CH3:37])[O:34][CH:33]([CH3:38])[CH2:32]1>>[ClH:28].[CH3:38][CH:33]1[O:34][CH:35]([CH3:37])[CH2:36][N:31]([CH2:30][CH2:29][O:17][C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][C:21]4[CH:24]=[CH:25][S:26][C:20]=4[CH:19]=2)=[CH:8][C:7]3=[N:6][OH:5])[CH2:32]1

참가 물질

3

반응물 2

HCID 129555394-(2-Chloro-ethyl)-2,6-dimethyl-morpholine hydrochlorideHCID 86673101HCID 86673101, 화합물

생성물 1

HCID 1371875856-[2-(2,6-Dimethyl-morpholin-4-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride

실험 절차

6-[2-(2,6-Dimethyl-morpholin-4-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride was prepared in 48% overall yield using the method described in example 127, starting from 6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime (example 127B) and 4-(2-Chloro-ethyl)-2,6-dimethyl-morpholine hydrochloride (JACS 1949, 500-505; US2006/14948).

후처리

  1. customoverall yield

출처 및 근거

ORD 기록
ord-359e4d5998dd4f5dbb5d57634467f503
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962627B2

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