3-Amino-2-phenyl-4(3H)-quinazolinone → 3-(1-adamantyl)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanamide

HRID 1853405노트

반응식

HRID 1853405 반응식
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:19]12([CH2:29][CH2:30][C:31](Cl)=[O:32])[CH2:28][CH:23]3[CH2:24][CH:25]([CH2:27][CH:21]([CH2:22]3)[CH2:20]1)[CH2:26]2>>[C:19]12([CH2:29][CH2:30][C:31]([NH:1][N:2]3[C:11](=[O:12])[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[N:4]=[C:3]3[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:32])[CH2:26][CH:25]3[CH2:24][CH:23]([CH2:22][CH:21]([CH2:27]3)[CH2:20]1)[CH2:28]2

참가 물질

3

반응물 2

HCID 7228763-Amino-2-phenyl-4(3H)-quinazolinoneHCID 155333063-(1-Adamantyl)propanoyl chloride

생성물 1

HCID 498725363-(1-adamantyl)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanamide

실험 절차

3-Amino-2-phenyl-4(3H)-quinazolinone and the product of Example 13A were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.93-1.13 (m, 2H), 1.23-1.33 (m, 6H), 1.51-1.65 (m, 6H), 1.85-1.89 (m, 3H), 1.96-2.08 (m, 2H), 7.44-7.55 (m, 3H), 7.58-7.64 (m, 3H), 7.75 (d, J=7.8 Hz, 1H), 7.89-7.94 (m, 1H), 8.18 (dd, J=8.0, 1.2 Hz, 1H), 11.06 (s, 1H) ppm; MS (DCI/NH3) m/z 428 (M+H)+; Elemental Analysis: Calculated for C27H29N3O2: C, 75.85; H, 6.84; N, 9.83. Found: C, 75.75; H, 6.97; N, 9.84.

출처 및 근거

ORD 기록
ord-b3d71d1180994b728fbba986b7c0404a
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962639B2

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