Pinacol → 3-Chloropropenyl-1-boronic acid pinacol ester
반응식
[Cl:1][CH2:2]/[CH:3]=[CH:4]/[B:5]([OH:7])[OH:6].O[C:9]([C:12](O)([CH3:14])[CH3:13])([CH3:11])[CH3:10].S([O-])([O-])(=O)=O.[Mg+2]>C(Cl)Cl>[Cl:1][CH2:2]/[CH:3]=[CH:4]/[B:5]1[O:7][C:12]([CH3:14])([CH3:13])[C:9]([CH3:11])([CH3:10])[O:6]1참가 물질
5
실험 절차
A solution of (E)-3-chloroprop-1-enylboronic acid (5 g, 41 mmol), pinacol (4.9 g, 41 mmol), and magnesium sulfate (15 g, 120 mmol) in methylene chloride (100 mL) was stirred at room temperature for 18 h. The reaction mixture was filtered through silica gel and the filter cake was washed with methylene chloride. The filtrate was concentrated to afford the desired product (4.8 g, 60%) as a colorless oil: ESI MS m/z 203 [C9H16BClO2+H]+.
후처리
- filtrationThe reaction mixture was filtered through silica gel
- washthe filter cake was washed with methylene chloride
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-b6f8ebc4cc6a4d118f83508cf7823cbd
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08962648B2
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