(1-Methylcyclobutyl)amine → 5-(tert-Butyl)-3',4'-dichloro-3-(((1-methylcyclobutyl)amino)methyl)-[1,1'-biphenyl]-2-ol
반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=O)[C:8]([OH:19])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:22][C:23]1([NH2:27])[CH2:26][CH2:25][CH2:24]1>>[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[C:8]([OH:19])=[C:7]([CH2:20][NH:27][C:23]2([CH3:22])[CH2:26][CH2:25][CH2:24]2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]참가 물질
3
실험 절차
5-(tert-Butyl)-3′,4′-dichloro-3-(((1-methylcyclobutyl)amino)methyl)-[1,1′-biphenyl]-2-ol was prepared as a white solid using the procedure described in Example 5 from 5-(tert-butyl)-3′,4′-dichloro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde (from Example 19, Step 1) and 1-methylcyclobutylamine.
출처 및 근거
- ORD 기록
- ord-ec5e4cf6945d483cb1fda9ad2a040c3a
- 출처 데이터셋
- uspto-grants-2015_02