Acetyl chloride → methyl 2-bromo-D-phenylalaninate hydrochloride
반응식
[Br:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][C@H:5]([C:7]([OH:9])=[O:8])[NH2:6].[C:14]([Cl:17])(=O)C>CO>[ClH:17].[Br:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][C@H:5]([C:7]([O:9][CH3:14])=[O:8])[NH2:6]참가 물질
4
실험 절차
Dissolve 2-bromo-D-phenylalanine (22.4 g, 91.8 mmol) in methanol (459 mL). Add acetyl chloride (65.3 mL, 917.7 mmol) at room temperature. Stir for 36 hours. Concentrate under reduced pressure to give the title compound (27.2 g, 92.3 mmol). MS (m/z): 258 (M+1).
후처리
- customat room temperature
- concentrationConcentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-8063687b5ec2455dabf95f5caa4ac33f
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08962654B2
반응 노트
불러오는 중…