Diiodoethane → HCID 53311312, 화합물

HRID 1854612노트

반응식

HRID 1854612 반응식
Cl[C:2]1[O:3][C:4]([C:7]2[N:12]=[C:11]([NH:13][C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][N:15]=3)[CH:10]=[CH:9][CH:8]=2)=[CH:5][N:6]=1.CC1C=CN=C(NC2C=CC=C(C3OC=NC=3)N=2)C=1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C.[I:50]C(I)C>C1COCC1>[I:50][C:2]1[O:3][C:4]([C:7]2[N:12]=[C:11]([NH:13][C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][N:15]=3)[CH:10]=[CH:9][CH:8]=2)=[CH:5][N:6]=1

참가 물질

6

반응물 4

HCID 68980DiiodoethaneHCID 2733832Lithium HexamethyldisilazideHCID 53311228(4-Methyl-pyridin-2-yl)-(6-oxazol-5-yl-pyridin-2-yl)-amineHCID 53311311HCID 53311311, 화합물

생성물 1

HCID 53311312HCID 53311312, 화합물수율 41%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The 2-iodooxazole derivative was prepared as for [6-(2-chloro-oxazol-5-yl)-pyridin-2-yl]-(4-methyl-pyridin-2-yl)-amine above from (4-methyl-pyridin-2-yl)-(6-oxazol-5-yl-pyridin-2-yl)-amine with LiHMDS (1M solution in THF) and diiodoethane in anhydrous THF to give the title compound as a yellow solid (41%) after purification by column chromatography on SiO2 eluting with 40% EtOAc in cyclohexane. 1H NMR (300 MHz, DMSO-d6) δ=9.81 (s, 1H), 8.10 (d, J=5.0 Hz, 1H), 7.84-7.51 (m, 4H), 7.23 (d, J=7.2 Hz, 1H), 6.77 (d, J=4.6 Hz, 1H), 2.33 (s, 3H).

출처 및 근거

ORD 기록
ord-55db21df8a534c34910011a2d7d6c548
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962665B2

반응 노트

불러오는 중…