7-Fluoro-2,3-dihydro-1h-indol-2-one → 7-fluoro-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-1,3-dihydro-2H-indol-2-one

반응식

[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2.Cl[C:13]1[N:18]=[C:17]([O:19][CH3:20])[N:16]=[C:15]([CH3:21])[N:14]=1>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH:7]2[C:13]1[N:18]=[C:17]([O:19][CH3:20])[N:16]=[C:15]([CH3:21])[N:14]=1

참가 물질

반응물 2

HCID 37343717-Fluoro-2,3-dihydro-1h-indol-2-one

HCID 193920792-Chloro-4-methoxy-6-methyl-1,3,5-triazine

생성물 1

HCID 867067347-fluoro-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-1,3-dihydro-2H-indol-2-one

실험 절차

7-Fluoro-1,3-dihydro-2H-indol-2-one (3.05 g) and 2-chloro-4-methoxy-6-methyl-1,3,5-triazine (6.59 g) are reacted analogously to Example 1 Variant A. This gives the title compound as solid in an HPLC purity of 85% area (4.73 g, 73% of theory).

출처 및 근거

ORD 기록: ord-dc1b5fa16e2a4d37a17fa070e75aace6
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08962828B2

반응 노트

불러오는 중…