HCID 86701036, 화합물 → 1,1-Dimethylethyl N-[1-(2-hydroxyethyl)cyclopropyl]carbamate

HRID 1855193노트

반응식

HRID 1855193 반응식
[Si]([O:8][CH2:9][CH2:10][C:11]1([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:13][CH2:12]1)(C(C)(C)C)(C)C>C(Cl)Cl>[OH:8][CH2:9][CH2:10][C:11]1([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20])[CH2:12][CH2:13]1

참가 물질

3

반응물 1

HCID 86701036HCID 86701036, 화합물

생성물 1

HCID 129931391,1-Dimethylethyl N-[1-(2-hydroxyethyl)cyclopropyl]carbamate수율 60.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)cyclopropylcarbamate (11.9 g, 37.8 mmol) and 3HF.TEA (22.0 g) in DCM (50 mL) was stirred at rt for 17 hrs. The mixture was concentrated and the residue was purified by silica gel column chromatography (0˜20% gradient elution EtOAc/petroleum ether) to afford tert-butyl 1-(2-hydroxyethyl)cyclopropylcarbamate (4.6 g, 60%) as a white solid.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (0˜20% gradient elution EtOAc/petroleum ether)

출처 및 근거

ORD 기록
ord-9f70371c2a7341a5bf5926a5aa0116c3
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962843B2

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