tert-Butoxy bis(dimethylamino)methane → 1-Dimethylamino-2-methyl-4-phenyl-pent-1-en-3-one

HRID 1855331노트

반응식

HRID 1855331 반응식
[C:1]1([CH:7]([C:9](=[O:12])[CH2:10][CH3:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O[CH:18]([N:22]([CH3:24])[CH3:23])N(C)C)(C)(C)C>>[CH3:24][N:22]([CH3:23])[CH:18]=[C:10]([CH3:11])[C:9](=[O:12])[CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:8]

참가 물질

3

반응물 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 41445242-Phenylpentan-3-one

생성물 1

HCID 686313161-Dimethylamino-2-methyl-4-phenyl-pent-1-en-3-one수율 117.6%

실험 절차

A mixture of 2-phenyl-3-pentanone (106 mg, 0.54 mmol) and of tert.-butoxy-bis(dimethylamino)methane (146 mg, 0.75 mmol, 90%) was stirred at 110° C. for 16 h. The reaction was evaporated to dryness, treated twice with toluene and the solvent was evaporated under reduced pressure to give the crude title compound (138 mg, 97%) as a dark brown solid which was used directly in the next step without further purification.

후처리

  1. customThe reaction was evaporated to dryness
  2. additiontreated twice with toluene
  3. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-14c388b9ab404673a2163916c26483b8
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962834B2

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