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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1855372생성일: 2026년 10월 26일

(2E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one → [4-(4-Chloro-phenyl)-pyrimidin-2-yl-3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

https://huagongshe.com/reaction/1855372

반응식

참여 물질

역할이름HCID투입량
반응물(2E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 605938—
반응물HCID 178493228HCID 178493228—
생성물[4-(4-Chloro-phenyl)-pyrimidin-2-yl-3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amineHCID 131732515—

반응 단계

The title compound was prepared from crude 1-(4-chloro-phenyl)-3-dimethylamino-propenone (87 mg, 0.3 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (83 mg, 0.22 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (29 mg, 33%). Mp 202-204° C.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08962834B2
출처 데이터셋uspto-grants-2015_02
ORD IDord-c58baddf01264b76ab5143bd326eeb10
출처 메모uspto-grants-2015_02