2-benzyl-4,6-dichloropyrimidine → HCID 44192796, 화합물

HRID 1855404노트

반응식

HRID 1855404 반응식
[CH2:1]([C:8]1[N:13]=[C:12]([Cl:14])[CH:11]=[C:10](Cl)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([NH2:30])[CH:21]=[CH:22][C:23]=1[N:24]1[CH:28]=[C:27]([CH3:29])[N:26]=[CH:25]1>>[CH2:1]([C:8]1[N:9]=[C:10]([NH:30][C:20]2[CH:21]=[CH:22][C:23]([N:24]3[CH:28]=[C:27]([CH3:29])[N:26]=[CH:25]3)=[C:18]([O:17][CH3:16])[CH:19]=2)[CH:11]=[C:12]([Cl:14])[N:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 27752592-benzyl-4,6-dichloropyrimidineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

생성물 1

HCID 44192796HCID 44192796, 화합물수율 48%

실험 절차

The title compound was prepared in analogous manner as described in example 62 from 2-benzyl-4,6-dichloro-pyrimidine and 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine. Obtained as yellow solid in 48% yield after column chromatography of the crude product on silica gel using dichloromethane/methanol (98:2 and then 95:5 v/v) as eluent.

출처 및 근거

ORD 기록
ord-70688ba1734d47fbb5ff4374e3542585
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962834B2

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