Isopropylamine → HCID 528635, 화합물

HRID 1855616노트

반응식

[C:1]([NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8])(C)([CH3:3])[CH3:2].C(N)(C)C.C(N(CC)CC)C.C(Cl)(=O)C(C)(C)C>>[CH:1]([NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8])([CH3:3])[CH3:2]

참가 물질

반응물 4

HCID 6363Isopropylamine

HCID 8471Triethylamine

HCID 62493Pivaloyl chloride

HCID 299326N-tert-Butylpivalamide

생성물 1

HCID 528635HCID 528635, 화합물수율 96%

실험 절차

In a fashion similar to the preparation of LtBu,tBuH, treatment of isopropylamine (9.0 mL, 105 mmol) and triethylamine (14.9 mL, 105 mmol) with pivaloyl chloride (8.9 mL, 100 mmol) afforded LtBu,iPrH as white crystalline solid (13.75 g, 96%) upon sublimation at 55° C./0.05 Torr: mp 106-108° C.

출처 및 근거

ORD 기록: ord-37851dbe5a584ace904b771f16bdcc4e
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08962876B2

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