Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HCID 178510940, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 3-(1-trityl-1H-imidazol-4-yl)propan-1-amine | HCID 15345825 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 178510940 | HCID 178510940 | — |
반응 단계
2 ml of trifluoroacetic acid are added to 195 mg (0.53 mmol) of 3-(1-trityl-1H-imidazol-4-yl) propylamine dissolved in 8 ml of DCM and then immersed in an ice bath. After warming to room temperature, the reaction medium is stirred for 2 hours and the solvents are then evaporated off. The solid obtained is taken up in EtOAc and water. The aqueous phase is then concentrated and 110 mg of a white powder are obtained and used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08962846B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-e5f2840a2cd44d209ed34f98dc3dd253 |
| 출처 메모 | uspto-grants-2015_02 |