Potassium Cyanide → 2-(1-Bromonaphthalen-2-yl)acetonitrile
반응식
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12]Br.[C-:14]#[N:15].[K+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl.O>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][C:14]#[N:15]참가 물질
6
실험 절차
A mixture of 99 parts of 1-bromo-2-(bromomethyl)naphthalene, 103 parts of potassium cyanide and 1 part of benzyl triethylammonium chloride in 150 parts by volume of methylene chloride and 30 parts by volume of water is stirred at room temperature for about 72 hours. The mixture is then diluted with additional quantities of methylene chloride and water, the organic layer separated, dried over calcium sulfate, and concentrated to give α-(1-bromo-2-naphthyl)acetonitrile, as a solid.
후처리
- customthe organic layer separated
- dry with materialdried over calcium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-3bf92dfc906f4dae8a086f25c09d43de
- 출처 데이터셋
- uspto-grants-1980_08
- 특허 번호
- US04217306
반응 노트
불러오는 중…