5-Tert-butyl-m-xylene → 4-tert-butyl-2,6-dimethylbenzenesulfonyl chloride

반응식

[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH3:6][C:7]1[CH:8]=[C:9]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:10]=[C:11]([CH3:13])[CH:12]=1>>[C:14]([C:9]1[CH:8]=[C:7]([CH3:6])[C:12]([S:2]([Cl:1])(=[O:5])=[O:3])=[C:11]([CH3:13])[CH:10]=1)([CH3:17])([CH3:16])[CH3:15]

참가 물질

반응물 2

HCID 73785-Tert-butyl-m-xylene

HCID 24638Chlorosulfonic acid

생성물 1

HCID 38685064-tert-butyl-2,6-dimethylbenzenesulfonyl chloride

반응 조건

온도: 0 °C

실험 절차

85 ml Chlorosulphonic acid (1.3 mole) was added to a mixture of 81 g (0.5 mole) 3,5 -dimethyl-tert.-butylbenzene at 0± 2° C. The reaction mixture was stirred at 0° C. for 1.5 hours, poured on ice and the layers were separated. The organic layer was washed with water, sodium bicarbonate, and water and was then dried with sodium sulphate. The solvent was removed in vacuum giving pale-yellow crystals of the title compound, m.p. 65° C.

후처리

additionpoured on ice
customthe layers were separated
washThe organic layer was washed with water, sodium bicarbonate, and water
dry with materialwas then dried with sodium sulphate
customThe solvent was removed in vacuum

출처 및 근거

ORD 기록: ord-d05a79bf95d44af2b0711589058f59fa
출처 데이터셋: uspto-grants-1980_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04218476

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