Sulfur → HCID 12891716, 화합물

HRID 1856566노트

반응식

HRID 1856566 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([N:11]([CH2:26][CH3:27])[CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:14][CH2:13]1)=S.[S]>[Hg]=O.CO>[CH2:26]([N:11]([CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:14][CH2:13]1)[C:9]1[NH:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=1)[CH3:27]

참가 물질

5

반응물 2

HCID 5362487SulfurHCID 12891715HCID 12891715, 화합물

생성물 1

HCID 12891716HCID 12891716, 화합물수율 43%

시약·촉매·용매 2

HCID 30856Mercuric oxide촉매HCID 887Methanol용매

실험 절차

A mixture of 39.8 parts of N-(2-aminophenyl)-N'-ethyl-N'-[I-(2-phenylethyl)-4-piperidinyl]thiourea, 15 parts of mercury oxide, 0.1 parts of sulfur and 400 parts of methanol is stirred and refluxed overnight. The reaction mixture is filtered hot over Hyflo and the filtrate is evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 14.5 parts (43%) of N-ethyl-N-[I-(2-phenylethyl)-4-piperidinyl]-1H-benzimidazol-2-amine; mp. 204.9° C.

후처리

  1. temperaturerefluxed overnight
  2. filtrationThe reaction mixture is filtered hot over Hyflo
  3. customthe filtrate is evaporated
  4. customThe residue is crystallized from 4-methyl-2-pentanone
  5. filtrationThe product is filtered off
  6. customdried

출처 및 근거

ORD 기록
ord-1c6ea741abcc417cafc6a1c603e576f2
출처 데이터셋
uspto-grants-1980_08
특허 번호
US04219559

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