benzyl 3-aminosulfonyl-2(R)-methylpropionate → 3-aminosulfonyl-2(R)-methylpropionic acid

HRID 1856727노트

반응식

HRID 1856727 반응식
[NH2:1][S:2]([CH2:5][C@H:6]([CH3:17])[C:7]([O:9]CC1C=CC=CC=1)=[O:8])(=[O:4])=[O:3]>CO.[Pd]>[NH2:1][S:2]([CH2:5][C@H:6]([CH3:17])[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]

참가 물질

4

반응물 1

HCID 18738444benzyl 3-aminosulfonyl-2(R)-methylpropionate

생성물 1

HCID 187384353-aminosulfonyl-2(R)-methylpropionic acid수율 97.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A 100 mL Fisher/Porter vessel was charged with 1.1 g of crude benzyl 3-aminosulfonyl-2(R)-methylpropionate in 35 mL MeOH and a catalytic amount of 10% Pd-C. The mixture was hydrogenated at 50 psi for 24 hours, filtered through Celite and concentrated in vacuo to yield 700 mg of 3-aminosulfonyl-2(R)-methylpropionic acid as a clear oil. The crude acid was used without further purification.

후처리

  1. filtrationfiltered through Celite
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8915229032904d8bb12bc76afe4c4d94
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143747

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