Sodium Azide → 6-(3-Azidopropoxy)carbostyril
반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2.[N-:17]=[N+:18]=[N-:19].[Na+]>CN(C)C=O>[N:17]([CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2)=[N+:18]=[N-:19]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
A suspension of 6-(3-chloropropoxy)carbostyril (100 g) and sodium azide (33 g) in dimethylformamide is refluxed at 80° C. for 4 hours. After the mixture is allowed to cool, to the mixture is added ice-water, and the precipitated crystals are collected by filtration, washed with diethyl ether, and dried to give 6-(3-azidopropoxy)carbostyril (100 g) as a white powder.
후처리
- temperatureto cool, to the mixture
- filtrationthe precipitated crystals are collected by filtration
- washwashed with diethyl ether
- customdried
출처 및 근거
- ORD 기록
- ord-2ca5e81abc2e4b138cef66f3ed51cc9c
- 출처 데이터셋
- uspto-grants-2000_11
- 특허 번호
- US06143763
반응 노트
불러오는 중…