Acetylresorcinol → 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol

HRID 1857105

반응식

HRID 1857105 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.C([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[C:22]([OH:23])[CH:21]=1)(=O)C.C(=O)([O-])O.[Na+]>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:19][C:20]1[CH:26]=[CH:25][CH:24]=[C:22]([OH:23])[CH:21]=1

참가 물질

4

반응물 3

HCID 5055AcetylresorcinolHCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 516892Sodium Bicarbonate

생성물 1

HCID 226465273-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol수율 9%

반응 조건

온도
180 °C

실험 절차

4-Chloro-6,7-dimethoxyquinoline (300 mg) and commercially available resorcinol monoacetate (0.835 ml) were mixed and stirred at 180° C. for 30 minutes. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate and then partitioned between water and ethyl acetate, and the ethyl acetate layer was washed with brine and then dried with anhydrous sodium sulfate. After removing the solvent by reduced-pressure distillation, the resulting residue was crystallized with chloroform to obtain 37 mg of the title compound (yield: 9%).

후처리

  1. custompartitioned between water and ethyl acetate
  2. washthe ethyl acetate layer was washed with brine
  3. dry with materialdried with anhydrous sodium sulfate
  4. customAfter removing the solvent
  5. distillationby reduced-pressure distillation
  6. customthe resulting residue was crystallized with chloroform

출처 및 근거

ORD 기록
ord-4432125e71764daeb1697b6327f5d441
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

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